Polyene macrolides are one of the groups of secondary metabolites, generated by microorganisms belonging to the Streptomyces genus. These compounds, containing 3 - 7 conjugated double bonds systems in their molecules exhibit high antifungal activity against a broad spectrum of fungal pathogens with heptaenes demonstrating the highest antifungal potential. At the large extent, efficiency of biosynthesis of these natural products depends on composition of the fermentation medium. For example, biosynthesis of candicidin, an aromatic heptaene by Streptomyces griseus is limited by the glucose content in the production medium. Addition of soybean or corn oil to the medium had stimulating effect on polyene production and considerably improved antibiotic yield. On the other hand, increasing concentration of inorganic phosphate limited antibiotic production by repression of activity of PABA synthetase, a key enzyme committed with macrolide biosynthesis [1]. Acetate and propionate units as a starter building materials in the polyketide pathway have small edification comparison to lower alcohols [2]. [1] Martin, J.F., McDaniel, L.E., (1976) Biosynthesis of Candicidin by Phosphate-Limited Resting Cells of Streptomyces griseus. European J. Appl. Microbiol. 3: 135-144[2] Õmura, S., (1984) Macrolide Antibiotics: Chemistry, Biology, and Practice. Academic Press, INC. Orlando, Florida. 391-422
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Additional information
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2010
