Aims: Aimof the study was to determine the role of perfusion chest computed tomography(pCT) in evaluation of pulmonary diabetic angiopathy.Methods: 18 never-smoking patients (10 diabetic patients and 8 healthy controls) underwentchest high resolution CT (HRCT) and then pCT scanning. In both groups, blood tests,biochemical analysis, fibrinogen, HbA1c, spirometry, diffusion capacity for carbonmonoxide(DLCO) and body pletysmography were performed.Following parameters of pulmonaryperfusion have been analysed: blood volume (BV), blood flow (BF), mean transit time(MTT), time to peak (TTP) and permeability surface (PS).Results: There were no statistically significant differences between groups in terms of age,sex, BMI, forced expiratory volume in one second (FEV1), DLCO. Chest HRCT revealed nopathologies. Significantly higher values of chest pCT for BF ( p = 0.05), BV ( p = 0.05) and PS( p = 0.01) have been found in diabetics in comparison to controls. No differences were foundin MTT.Conclusions: Significant increase of perfusion parameters in diabetes seems to confirmpulmonary microangiopathy. The results indicate that further studies on application ofpCT in diabetic patients may be beneficial for better understanding of lung microangiopathy, its diagnosing and monitoring.
Authors
- Krzysztof Kuziemski,
- J Pieńkowska,
- Wojciech Słomiński link open in new tab ,
- Jakub Specjalski link open in new tab ,
- K Dziadziuszko,
- J Jassem,
- M Studniarek,
- prof. dr hab. inż. Renata Kalicka link open in new tab ,
- J Słomiński
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.diabres.2010.11.004
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2010
