Impurity profiling and classification of seized methamphetamine may supply valuable information with respect to the conditions and the chemicals used in the illicit methamphetamine manufacture and may provide information on the original source of the sample. Determination of the stereochemical makeup of forensic samples is important as well for the same reasons. Laboratories in many places are engaged in clandestine manufacture of methamphetamine. There are two major synthetic approaches for the preparation of methamphetamine: one is synthesis from 1-phenyl-2-propanone (P-2-P), which is a precursor for the Leuckart method or reductive amination, and the other is synthesis from l-ephedrine or d-pseudoephedrine via Birch reduction, Nagai method, or Emde method. This study a focus on the stereochemical course of part I of the EMDE method involving the synthesis chloroephedrines, and chloropseudoephedrines via chlorination of ephedrine and pseudoephedrine. The configuration of these chloroamines were determined by NMR analysis.
Authors
Additional information
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2011
