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Common methods for the chiral determination of amphetamine and related compounds I. Gas, liquid and thin-layer chromatography

This article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-deriveddesigner drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into considerationarticles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thinlayer). We describe several types of chiral derivatization reagent, mobile-phase additive and chiral stationary phase commonlyused in the chromatographic methods. Tables summarize basic information about conditions (e.g., type of column and mobilephase), detection mode and reference data for each procedure.

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