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Gdańsk University of Technology

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Synthesis of new antrapyridazone derivatives - a novel group of anticancer agents active on a multidrugresistant(MDR) tumor cell lines

Novel antrapyridazone derivatives were synthesized and biologically evaluated in order tobroaden the data on structure-activity relationship of this class of cytostatics. Recent literaturedata prove that acetamides react better with aryl chlorides. A new approach based onintroduction of other amides form into aromatic ring in Ullmann was tested. This new methodcould give better yields and make purification step more convenient.

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Additional information

Category
Aktywność konferencyjna
Type
publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
Language
angielski
Publication year
2010

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