In this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these physiological systems interact with each other and bring about regeneration is explored.
Authors
- L. Matthew Arthur,
- prof. dr hab. inż. Paweł Sachadyn link open in new tab ,
- Dmitri Gourevitch,
- Ellen Heber-Katz
Additional information
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2011
Source: MOSTWiedzy.pl - publication "Cardinal regenerative features of the MRL mouse" link open in new tab
