The multi-residue analytical method developed, based on accelerated solvent extraction, gel permeation chromatography purification and UPLC-MS/MS analysis allowed the simultaneous determination of 21 pharmaceuticals. Recoveries obtained for most of the target compounds were higher than 50%. The application of UPLC-MS/MS operating in the MRM mode, with two transitions monitored for each compound, provided good sensitivity and selectivity. The method presented detection limits in the low ng/g range for the three fish species, thus providing a reliable and robust tool that can be used for routine analysis of multi-class pharmaceuticals in fish tissues. Anti-inflammatories, psychiatric drugs and β-blockers were found in fish samples from the most polluted sites of Mediterranean rivers in the range of 0.6-15 ng/g.
Authors
- Belinda Huerta,
- Anna Jakimska-Nagórska link open in new tab ,
- Meritxell Gros,
- Sara Rodriguez-Mozaz,
- Damia Barcelo
Additional information
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2012
