Diels Alder reaction is a very important tool in carbon-carbon bond formation. It is a cycloaddition between a conjugated diene and a second compound called dienophile. Where one or more heteroatoms are present in the diene and/or dienophile framework, the cycloaddition is called hetero-Diels-Alder reaction (HDA). The asymmetric Diels-Alder reaction is among the most powerful available methodologies for that construction of optically active molecules, with extensive synthetic applications in natural or unnatural products with a wide range of biological activity. Different kinds of catalysts are used to receive the desired compound in a high yield. In the last decades Schiff base (e.g. salen) complexes of transition metal ions have gained much popularity in asymmetric catalysis. Chiral salen ligands are easily synthesized starting from enantiomerically pure diamines and two moles of salicylic aldehyde or its derivatives. For most of the transition metals, the corresponding metallic complex using salen as ligand has been reported (Mn, Cr, Co, V, Cu, Ti, Ru, Pd, Au, Zn, and Al). Most of them are also used in the title reaction. This paper is dedicated to the exploitation of metal-salen chiral complexes in the Diels-Alder reaction.
Authors
Additional information
- Category
- Publikacja monograficzna
- Type
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Language
- angielski
- Publication year
- 2012
