MutS and MutL proteins are renowned mostly for their functions in well-characterized, post-DNA replication mis- match repair system (MMR). However, there is growing evidence that MMR system is not the only field of action for these pro- teins. Moreover, the participation in MMR does not even have to be their primary function. There are some reports indicat- ing involvement of MutL in BER, NER and VSP (very short patch repair). MutL protein interacts with MMR proteins such as MutS, MutH, UvrD, ExoX as well as with proteins which do not belong to MMR proteins family: ß and subunits of DNA polymerase III and RecA protein. The ability of MutL to interact structurally and functionally with a number of different proteins makes this protein a perfect candidate for the master regulator coupling MMR system with other DNA repair mechanisms
Authors
Additional information
- Category
- Publikacja monograficzna
- Type
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Language
- angielski
- Publication year
- 2013
