The mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore, the mammalian cardiomyocyte withdraw from the cell cycle seems to be the biggest barrier for the regeneration in adult organisms. Hence, the analysis of the mechanisms that guide this transition in the neonatal life may be employed to awake the dormant regenerative potential of the heart. In this paper the recent findings on the neonatal heart regeneration have been presented.
Authors
Additional information
- Category
- Publikacja monograficzna
- Type
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Language
- angielski
- Publication year
- 2013
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