Publications Repository - Gdańsk University of Technology

In search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally, the cytotoxic properties depends on the substituent and configuration at chiral center in amino acid unit. Three derivatives revealed higer potency than parent MPA.

Authors

• mgr inż. Dorota Iwaszkiewicz-Grześ link open in new tab ,
• dr hab. inż. Grzegorz Cholewiński link open in new tab ,
• prof. dr hab. inż. Agata Kot-Wasik link open in new tab ,
• Piotr Trzonkowski,
• prof. dr hab. inż. Krystyna Dzierzbicka link open in new tab