Infections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and genotypic methods. Test performed in vitro are not in agreement with the results showing the occurrence of genes involved in biofilm production. Moreover genotypic methods are focused mainly only on the amplification of two genes of the icaADBC operon, icaA and icaD genes. More efforts should be devoted to identify the regulatory proteins of biofilm production such as SarA, Agr, Bap or alternative sigma factor δB. Getting knowledge about regulatory mechanism of biofilm formation could result in finding novel molecular target for antibacterial therapy, especially infection caused by staphylococci.
Authors
Additional information
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2013
