To limit the cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. We have shown that the improved by us synthesis of the conjugate of doxorubicin with iron-oxide magnetic nanoparticles allows a substantial depression of the aggregation process of the nanoparticles and therefore the examination of cytotoxicity of the modified drug. It has been shown that the use of magnetic field guarantees the efficient delivery of the drug to the desired place and an increase in the number of DOX molecules to one magnetic particles was achieved. It has also been found that the release of the drug takes place below pH 6, which characterizes the cancer cells. It has also been found that while the iron oxide magnetic nanoparticles were not cytotoxic toward human urinary bladder carcinoma cells UM-UC-3, the tumor cell sensitivity of the DOX-Np complex was slightly higher in comparison to the identical concentration of doxorubicin alone.
Authors
- Anna M. Nowicka,
- Agata Kowalczyk,
- Anita Jarzębińska,
- Mikołaj Donten,
- Paweł Krysiński,
- Zbigniew Stojek,
- dr hab. Ewa Augustin link open in new tab ,
- prof. dr hab. inż. Zofia Mazerska link open in new tab
Additional information
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2013
