20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more potent DPPH radical scavenging acitivities, but superoxide anion quenching ability is better for benzohydroxamic acids bearing electron-donating substituents.
Authors
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.5012/bkcs.2013.34.10.3098
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2013
