Publications Repository - Gdańsk University of Technology

3-MCPD is a heat-induced food contaminant which has been widely investigated for decades. This paper presents an overview of current knowledge about 3-MCPD including its formation routes, occurrence in various foodstuffs, analytical approach, toxicological aspects and future research perspectives. So far 3-MCPD was determined in its free and bound form in thermally-treated foods, edible oils and fats, and infant foods including human breast milk. Infant foods and human breast milk were highlighted in this paper as a serious problem due to the fact that they can pose a potential hazard for infants. The analytical approach of 3-MCPD determination have been modified for over a decade. Nowadays the method based on determining the derivative of this compound by using GC-MS is widely used. However there is still a big need for developing new methods which would produce repeatable results. Some of the toxicological aspects associated with 3-MCPD still remain unknown. A number of studies on carcinogenicity and genotoxicity of 3-MCPD were carried out on rodents however no clinical studies on humans have been reported so far. Also, both detrimental effect on kidneys and antifertility activity have been widely reported. Moreover, the knowledge about 3-MCPD absorption into body fluids and tissues, and its metabolic pathways is based on sometimes conflicting data derived from different studies. In conclusion, although a lot of research was carried out on the topic of 3-MCPD, there is still a need for further research in this area.

Authors

• dr inż. Renata Marcinkowska link open in new tab ,
• Magdalena Kupska link open in new tab ,
• dr inż. Agnieszka Głowacz-Różyńska link open in new tab ,
• dr inż. Justyna Gromadzka link open in new tab ,
• prof. dr hab. inż. Jacek Namieśnik link open in new tab