For many decades it was an accepted dogma of molecular genetics that the expression of genes is a “one-way-road” leading only in one direction from DNA to RNA to proteins. Recent discoveries in modern molecular genetics have challenged this dogma showing that specific RNA molecules play a central role in controlling the activity of genes by changing the structure of DNA sequences, targeting other RNAs for degradation or blocking the translation of messenger RNAs into proteins. Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In order to organize important data of siRNA, easy access tool is developed using WAMP server and PHP programming. In this tool, four different organism (mouse, rat, hepatitis B virus and hepatitis C virus) and their related siRNA data are stored which include information about gene and sequence of siRNA. All these details have cross-linked with other databases. This tool gives provision to researchers to submit newly discovered sequences with experimental references.
Authors
Additional information
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2015
