Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase

Dorota Pawlak; Schielmann Marta; Marek Wojciechowski; Ryszard Andruszkiewicz

doi:10.1016/j.bmcl.2016.06.016

A short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also potent inhibitory activity against fungal glucosamine-6-phosphate synthase comparable to that of FMDP.

Authors

mgr inż. Dorota Pawlak link open in new tab ,
dr inż. Schielmann Marta,
dr hab. inż. Marek Wojciechowski link open in new tab ,
prof. dr hab. inż. Ryszard Andruszkiewicz link open in new tab

Additional information

DOI: Digital Object Identifier link open in new tab 10.1016/j.bmcl.2016.06.016
Category: Publikacja w czasopiśmie
Type: artykuł w czasopiśmie wyróżnionym w JCR
Language: angielski
Publication year: 2016

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