This paper presents the synthesis of two new (p-cymene)-ruthenium(II) complexes with the bidentate coumarin ligands. Both complexes were characterized by FTIR spectroscopy, 1H NMR, 13C NMR, MS, elemental analysis and DFT calculations. The X-ray structure of complex 3a was also solved. The cytotoxic properties of both complexes were examined on human leukemia NALM-6 and HL-60 cells and melanoma WM-115 cells. The complexes possess higher cytotoxic activity than the ligands, The results of DFT calculations performed at the BP86-D3/QZ4P level for Ru(II) complexes and Pd(II) complexes with the same ligands indicate that Pd(II) complexes are more lipophilic. Moreover the RP-TLC-Based Lipophilicity assessment was also performed.
Authors
- Anna Skoczynska,
- Karin Lux,
- Peter Mayer,
- Ingo-Peter Lorenz,
- Urszula Krajewska,
- Marek Rozalski,
- prof. dr hab. inż. Anna Dołęga link open in new tab ,
- Elzbieta Budzisz
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.ica.2016.10.036
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2017
