Mouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin healing. The expression of transcription factor Foxn1 in the epidermis of mouse fetuses begins at embryonic day 16.5 which coincides with the transition point from scar-free to scar-forming skin wound healing. In the present study, we tested the hypothesis that Foxn1 expression in the skin is an essential condition to establish the adult skin phenotype and that Foxn1 inactivity in nude mice keeps skin in the immature stage resembling the phenomena of neoteny.
Authors
- Anna Kur-Piotrowska,
- Marta Kopcewicz,
- Leslie Kozak,
- prof. dr hab. inż. Paweł Sachadyn link open in new tab ,
- Anna Grabowska,
- Barbara Gawronska-Kozak
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1186/s12864-016-3401-z
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2017
