6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl transferase, but at millimolar concentrations. Both compounds and their N-acetyl derivatives exhibited antimicrobial in vitro activity, with MICs in the 0.125–2.0 mg mL−1 range. Antibacterial but not antifungal activity of GlcN6S was potentiated by D-glucosamine and a synergistic antibacterial effect was observed for combination of ADGP and a dipeptide Nva-FMDP.
Authors
- Kornelia Skarbek link open in new tab ,
- dr hab. inż. Iwona Gabriel link open in new tab ,
- dr hab. inż. Piotr Szweda link open in new tab ,
- dr hab. inż. Marek Wojciechowski link open in new tab ,
- Muna Khan,
- Görke Boris,
- prof. dr hab. inż. Sławomir Milewski link open in new tab ,
- prof. dr hab. inż. Maria Jolanta Milewska link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.carres.2017.06.002
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2017
