Publications Repository - Gdańsk University of Technology

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics

Authors

• Sophie Grellet,
• dr hab. inż. Małgorzata Śmiałek-Telega link open in new tab ,
• Nigel J. Mason,
• Jon Golding