Publications Repository - Gdańsk University of Technology

The synthesis of a potential immunosuppressant, i.e. dimethyl ester of N-mycophenoyl malonic acid was optimized in the reaction of mycophenolic acid (MPA) with amino malonic dimethyl ester in the presence of propanephosphonic anhydride (T3P) as a coupling reagent. The structural properties of the obtained MPA derivative were investigated by NMR, MS and single crystal X-ray diffraction methods. Theoretical considerations of conformational flexibility based on DFT calculations are presented

Authors

• Agnieszka Siebert link open in new tab ,
• dr hab. inż. Grzegorz Cholewiński link open in new tab ,
• dr inż. Dorota Garwolińska link open in new tab ,
• mgr inż. Adrian Olejnik link open in new tab ,
• prof. dr hab. inż. Janusz Rachoń link open in new tab ,
• prof. dr hab. inż. Jarosław Chojnacki link open in new tab