Aspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H mutation (34 bp tandem repeats in the promotor region and single point mutations of cyp 51A gene resulting in the substitution of leucine for histidine in lanosterol 14 alpha-demethylase). It is suggested that the overuse of some fungicides in agriculture contribute to the selection of resistant mutants. The avian farms seems to be places of higher risk of contamination and subsequent infection caused by resistant Aspergillus fumigatus strains.
Authors
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1111/myc.12674
- Category
- Aktywność konferencyjna
- Type
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Language
- angielski
- Publication year
- 2017
