This Focus Review gathers together a selection of methods for the chemical phosphorylation of phenols that employ three‐ and four‐coordinate phosphorus compounds. Phosphorylated scaffolds can exhibit enhanced properties compared to their non‐phosphorylated analogues, such as increased biological activity and increased/decreased solubility; as such, phosphorus compounds have gained more and more interest in organic and medicinal chemistry. Phosphate esters are valuable intermediates in drug synthesis and, from this point of view, a knowledge of effective and selective methods for chemical phosphorylation is essential. Furthermore, phosphates form the basis of a large number of herbicides, insecticides, and nerve agents and they can act as flame retardants and plasticizers to protect or enhance the properties of various materials, such as textiles, furniture, or plastics.
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Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1002/ajoc.201700638
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2018