A plethora of analytical LC-MS-based methods have been successfully applied to analyses of complex samples of various origin for metabolomics investigations. Over the last ten years, the substantial evolution of ambient mass spectrometry (AMS) techniques has highlighted their tremendous potential in metabolomic studies due to the minimal sample pretreatment requirement and the ability to analyse samples in their native state. This review illustrates the present state of the art in application of the LC-MS- and AMS-based techniques in various fields of metabolomics. We focused on the AMS-based techniques that have most commonly been applied in metabolomicsstudies. Our review covers the main strategies and challenges identified in the implementation of these approaches, as well as key limiting factors, such as sample preparation, ionization techniques and quantitation capabilities. We believe that the present paper represents the first attempt to compare these two approaches and will be useful in future metabolomics studies.
Authors
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.trac.2018.09.010
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2018
