Publications Repository - Gdańsk University of Technology

The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0.202 ng/mL [0.150; 0.255] vs. 0.154 ng/ mL [0.106; 0.201], P=0.035), which correlated positively with serum total testosterone (TST) (R=0.285, P=0.004) and the free androgen index (FAI) (R=0.196, P=0.049). There were no significant correlations between serum BPA and BMI, waist circumference, serum glucose, insulin and lipids. These results point to the potential role of BPA in the pathogenesis of the ovarian hyperandrogenism in women with PCOS.

Authors

• Aleksandra Konieczna,
• Dominik Rachoń,
• Katarzyna Owczarek link open in new tab ,
• dr inż. Paweł Kubica link open in new tab ,
• Agnieszka Kowalewska,
• dr hab. inż. Błażej Kudłak link open in new tab ,
• prof. dr hab. inż. Andrzej Wasik link open in new tab ,
• prof. dr hab. inż. Jacek Namieśnik link open in new tab