In this paper, a spectroscopic method for determination of cyclosporine concentrations in biological fluids is presented. Blood plasma and hemoglobin solutions are chosen for the experiment. For various cyclosporine concentrations in blood plasma and hemoglobin, absorbance measurements in spectra range from 600 to 1100 nm are performed. The measurement results are analyzed by the use of a dedicated algorithm. The obtained data are characterized by a high coefficient of correlation R2, which is equal to 0.9461 and 0.9808 for blood plasma and hemoglobin, respectively. The proposed method enables the selective detection of cyclosporine level and could be applied in medicine and laboratory diagnostics. The obtained result can be the base to build the point‐of‐care CsA level detection optical sensor.
Authors
- Marcin Marzejon link open in new tab ,
- Monika Kosowska link open in new tab ,
- dr inż. Daria Majchrowicz link open in new tab ,
- Barbara Bułło‐Piontecka,
- dr. Michał Wąsowicz,
- prof. dr hab. inż. Małgorzata Szczerska link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1002/jbio.201800273
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2019
