Publications Repository - Gdańsk University of Technology

Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N ,N -dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.

Authors

• Barbara Dmochowska,
• Lucyna Pellowska-Januszek,
• Justyna Samaszko,
• Rafał Ślusarz link open in new tab ,
• Roland Wakieć link open in new tab ,
• Janusz Madaj