Novel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells (hepG2).
Authors
- Maja Przybyłowska link open in new tab ,
- Iwona Inkielewicz-Stępniak,
- mgr inż. Szymon Kowalski,
- prof. dr hab. inż. Krystyna Dzierzbicka link open in new tab ,
- dr hab. inż. Sebastian Demkowicz link open in new tab ,
- dr inż. Mateusz Daśko link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.2174/1573406415666190716115524
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2020
