Publications Repository - Gdańsk University of Technology

A series of fluorinated analogs based on the frameworks of 4-(1- phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates have been synthesized as steroid sulfatase (STS) inhibitors. The design of chemical structures of new potential STS inhibitors was supported by molecular docking techniques to identify potential interactions between inhibitors and amino acid residues located in the STS active site. The STS inhibitory potency was evaluated on STS isolated from human placenta. We found that compounds substituted with fluorine atom at the meta position demonstrated the highest inhibitory effects in enzymatic STS assay. The most active analog 12e – inhibited STS enzyme with the IC50 value of 36 nM.

Authors

• dr inż. Mateusz Daśko link open in new tab ,
• dr hab. inż. Sebastian Demkowicz link open in new tab ,
• prof. dr hab. inż. Janusz Rachoń link open in new tab ,
• dr inż. Karol Biernacki link open in new tab ,
• Justyna Aszyk link open in new tab ,
• Witold Kozak,
• Maciej Masłyk,
• Konrad Kubiński