Publications Repository - Gdańsk University of Technology

The chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the case of 1b. Our data show that the biological forms of the tumors responded to 1a and its 4-methylated analog in different ways. 1a and 1b could be inducers of regulated melanoma cell death, especially the amelanotic form. Although the mechanism of the cell death is not fully understood, 1b may act by interfering with the TAC enzymes and blocking specific pathways leading to tumor growth. This could encourage further investigation of its anticancer activity, especially against the amelanotic form of melanoma.

Authors

• Miroslawa Cichorek,
• Anna Ronowska link open in new tab ,
• prof. dr hab. inż. Krystyna Dzierzbicka link open in new tab ,
• dr inż. Monika Gensicka-Kowalewska link open in new tab ,
• Milena Deptuła,
• Iwona Pelikant-Malecka