Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications are mainly mediated by DNA methylation, histone acetylation, and the action of specific non-coding RNAs. It has been documented that the profile of epigenetic changes in patients with atopic dermatitis (AD) di ff ers from that observed in healthy people. This applies to the genes a ff ecting the regulation of immune response and inflammatory processes, e.g., both a ff ecting Th1 bias and promoting Th2 responses and the genes of innate immunity, as well as those encoding the structural proteins of the epidermis. Understanding of the epigenetic alterations is therefore pivotal to both create new molecular classifications of atopic dermatitis and to enable the development of personalized treatment strategies.
Authors
- Bogusław Nedoszytko,
- Edyta Reszka,
- Danuta Gutowska-Owsiak,
- Magdalena Trzeciak,
- Magdalena Lange,
- Justyna Jarczak,
- Marek Niedoszytko,
- Ewa Jablonska,
- Jan Romantowski,
- Dominik Strapagiel,
- Jarosław Skokowski link open in new tab ,
- Anna Siekierzycka,
- Roman J. Nowicki,
- Iwona T. Dobrucki,
- Anna Zaryczańska,
- prof. dr hab. lek. Leszek Kalinowski link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.3390/ijms21186484
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2020
