In this work, two different chromatographic methods for seasonal monitoring of pharmaceutical residue in wastewater samples were developed. In the case of enantiomeric separation of selected compounds, LC-MS technique combining with vancomycin based chiral stationary phase was used. The performance of chiral analysis enabled to monitor the pharmaceutical contamination at the enantiomeric level. The d-SPE procedure was developed as sample preparation step and compared with SPE protocol in terms of recoveries and environmental friendliness. Due to satisfactory recoveries (around 60%) and greener character assessed using GAPI and AGREE tools, d-SPE-LC-MS/MS method was applied in further analysis. The concentration of detected enantiomers in wastewater collected in different seasons did not exceed 10 µg L−1, whereas the evaluated EF values were generally in the range of 0.4–0.7. Moreover, no significant changes in EF values after wastewater treatment were observed.
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Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.microc.2020.105517
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2020