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Gdańsk University of Technology

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In Vitro Biological Characterization of Silver-Doped Anodic Oxide Coating on Titanium

Despite the high biocompatibility and clinical effectiveness of Ti-based implants, surface functionalization (with complex osteointegrative/antibacterial strategies) is still required. To enhance the dental implant surface and to provide additional osteoinductive and antibacterial properties, plasma electrolytic oxidation of a pure Ti was performed using a nitrilotriacetic acid (NTA)-based Ag nanoparticles (AgNP)-loaded calcium–phosphate solution. Chemical and structural properties of the surface-modified titanium were assessed using scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) and contact angle measurement. A bacterial adhesion test and cell culture biocompatibility with collagen production were performed to evaluate biological effectiveness of the Ti after the plasma electrolytic process. The NTA-based calcium– phosphate solution with Ag nanoparticles (AgNPs) can provide formation of a thick, porous plasma electrolytic oxidation (PEO) layer enriched in silver oxide. Voltage elevation leads to increased porosity and a hydrophilic nature of the newly formed ceramic coating. The silver-enriched PEO layer exhibits an effective antibacterial effect with high biocompatibility and increased collagen production that could be an effective complex strategy for dental and orthopedic implant development.

Authors

  • Oleksandr Oleshko,
  • Iryna Liubchak,
  • Yevheniia Husak,
  • Viktoriia Korniienko,
  • Aziza Yusupova,
  • Tetiana Oleshko,
  • Rafal Banasiuk,
  • dr hab. inż. Marek Szkodo link open in new tab ,
  • Igor-Matros Taranets,
  • Alicja Kazek-Kęsik,
  • dr inż. Wojciech Simka,
  • Maksym Pogorielov