Amino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing to controls. Results suggest that plasma free AA profile may serve as a prognostic biomarker.
Authors
- Dr Anna Synakiewicz,
- dr hab. inż. Anna Stanisławska-Sachadyn link open in new tab ,
- Dr n. med. Małgorzata Sawicka-Żukowska,
- Grażyna Gałęzowska,
- dr Joanna Ratajczyk,
- dr Anna Owczarzak,
- Małgorzata Skuza,
- Lidia Wolska,
- dr. hab. Teresa Stachowicz-Stencel
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1007/s00726-020-02910-8
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2021
