Publications Repository - Gdańsk University of Technology

The aim of this work is review of tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. In this account we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant, decreasing beta-amyloid plaque aggregation, nitric oxide production, pro-inflammatory cytokines release, monoamine oxidase-B activity, cytotoxicity and oxidative stress in vitro and in animal model that classify these hybrids as potential multifunctional therapeutic agents for Alzheimer's disease. Moreover, herein, we have described the cholinergic hypothesis, mechanisms of neurodegeneration and current pharmacotherapy of Alzheimer's disease which is based on the restoration of cholinergic function through blocking enzymes that break down acetylcholine.

Authors

• Maja Przybyłowska link open in new tab ,
• prof. dr hab. inż. Krystyna Dzierzbicka link open in new tab ,
• Szyman Kowalski,
• Klaudia Chmielewska link open in new tab ,
• Iwona Inkielewicz-Stępniak