Publications Repository - Gdańsk University of Technology

Polysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application of NPSA by categorizing them into generic and advanced application realms. First, application of NPSA as drug and gene delivery systems, along with their role in the field as antibacterial platform and hemostasis agent is discussed. Then, applications of NPSA for skin, bone, nerve, and cartilage tissue engineering are highlighted, followed by cell encapsulation and more critically cancer diagnosis and treatment potentials. In particular, three features of investigations devoted to cancer, i.e. radiotherapy, immunotherapy, and photothermal therapy, are comprehensively reviewed and discussed. Since this field experience an early-stage maturity, some other aspects such as bioimaging and biosensing are reviewed in order to give a sensation of potential applications of NPSA for future developments—providing a support for clinical applications. It is well-documented that using nanoparticles/nanomaterials above a critical concentration brings about concerns to toxicity, so that their effect on cellular interactions would become a criticism. We compared nanoparticles used in fabrication of NPSA in terms of toxicity mechanism to shed more lights on future challenging aspects of NPSA development. Indeed, neutralization mechanisms underlying cytotoxicity of nanomaterials, which are expected to be induced by polysaccharide introduction, should be taken into account for future investigations.

Authors

• Hanieh Shokrani,
• Amirhossein Shokrani,
• S. Mohammad Sajadi,
• Mohsen Khodadadi Yazdi,
• Farzad Seidi,
• Maryam Jouyandeh,
• Payam Zarrintaj,
• Saptarshi Kar,
• Seokjhin Kim,
• Tairong Kuang,
• Navid Rabiee,
• dr inż. Aleksander Hejna link open in new tab ,
• dr inż. Mohammad Saeb link open in new tab ,
• Seeram Ramakrishna