Ready-to-feed milk and powdered milk packed in different types of packaging lined with resin are chosen as the primary or complementary diet for infants and toddlers. An HPLC–MS/MS method was established and validated for the determination of nineteen bisphenols and their derivatives in such samples. The recoveries were from 31% to 120%, while the values of limit of detection and quantification were in the range of 0.24–0.40 and 0.72–1.2 ng/g, respectively. The method was applied to analyse 40 samples of milk from the Polish market. Ninety-five percent of the studied samples contained a quantified concentration of bisphenols in the range of 0.53–18.51 ng/g. The gathered data were used for exposure and hazard risk assessments using hazard quotient (HQ) and hazard index (HI) values. The mean estimated daily intake (EDI) of bisphenols was determined to be 22–1162 ng/kg b.w./day. The results indicate the consumption of the daily dose of milk and one ready-to-eat product does not exceed the limits of tolerable daily intake of bisphenols. The highest HI values were found in 4-month-old female (1.8). In the average-exposure scenario, no HI values> 1 were observed for any age group, whereas hazard is significantly increased taking into account EFSA (European Food Safety Authority) draft opinion.
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Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.jfca.2023.105366
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2023
