The study aims to optimize MAE of total phenolic compounds (TPC) and antioxidant capacity from Salvia officinalis L. leaves using a definitive screening design (DSD) and I-optimal design. UHPLC-HRMS analysis was used to identify and compare the composition of MAE and UAE optimal extracts. The results showed that DSD and I-optimal design were successfully applied for the optimization of MAE targeting phenolics and other antioxidants from S. officinalis L. with the following optimum conditions: 60% ethanolic solvent, time of 4.75 min, power of 600 W, and L/S ratio of 50 mL g 1. The UHPLC-MS analysis results allowed the identification of more than 80 compounds, and the differential analysis indicated that the MAE yielded a higher level of 181 substance peaks, while the UAE yielded a higher level of 87 substance peaks. This study provides valuable information for selecting the appropriate extraction technique when targeting specific compounds.
Authors
- Hamza Moussa,
- Farid Dahmoune,
- Marika Mróz link open in new tab ,
- Hocine Remini,
- Nabil Kadri,
- Sarah Hamid,
- dr hab. inż. Barbara Kusznierewicz link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.scp.2023.101194
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2023
