Publications Repository - Gdańsk University of Technology

The term ‘vitamin C’ describes a group of compounds with antiscorbutic activity of L-ascorbic acid (AA). Despite AA’s omnipresence in plant-derived foods, its derivatives have also been successfully implemented in the food industry as antioxidants, including the D-isomers, which lack vitamin C activity. This study aimed to determine the relationship between redox-related activities for five derivatives of AA using electrochemical, chemical, and biological approaches. Here we report that AA, C-vitamers, and other commonly consumed AA derivatives differ in their redox-related activities. As long as the physiological range of concentrations was maintained, there was no simple relationship between their redox properties and biological activity. Clear distinctions in antioxidant activity were observed mostly at high concentrations, which were strongly correlated with electrochemical and kinetic parameters describing redox-related properties of the studied compounds. Despite obvious similarities in chemical structures and antioxidant activity, we showed that C-vitamers may exhibit different nutrigenomic effects. Together, our findings provide a deeper insight into so far underinvestigated area combining chemical properties with biological activities of commonly applied AA derivatives.

Authors

• Patrycja Jakubek link open in new tab ,
• dr inż. Klaudia Suliborska link open in new tab ,
• dr mgr inż. Monika Kuczyńska,
• Muhammad Asaduzzamana,
• dr inż. Karol Parchem link open in new tab ,
• dr inż. Izabela Koss-Mikołajczyk link open in new tab ,
• dr hab. inż. Barbara Kusznierewicz link open in new tab ,
• dr hab. inż. Wojciech Chrzanowski link open in new tab ,
• prof. dr hab. inż. Jacek Namieśnik link open in new tab ,
• prof. dr hab. inż. Agnieszka Bartoszek-Pączkowska link open in new tab