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Publications Repository
Gdańsk University of Technology

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Microbiota-derived metabolites in colorectal cancer patients in preoperative period

Short-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently, metab-olome within the gut might change to a large ex-tent. Therefore, the aim of this study was to anal-yse the content of SCFAs and the proportion be-tween SCFAs in the stool obtained from CRC pa-tients in preoperative period. PATIENTS AND METHODS: This study in-cluded 15 patients with CRC in preoperative pe-riod. The stool samples were taken and stored at -80°C in the Fahrenheit Biobank BBMRI.pl, Med-ical University of Gdansk, Poland. The analysis of SCFAs from stool samples was conducted by means of gas chromatography. RESULTS: This study included mainly males (66.67%, n=10). In all patients, there was abnor-mal proportion between SCFAs. The extreme-ly higher concentration of butyrate was noted in 2 samples (13.33%) compared to the rest of pa-tients. However, based on normal proportion be-tween SCFAs, the results <1 for butyrate were noted in 93.33% of patients. CONCLUSIONS: SCFAs pool is altered in CRC patients, among others characterized by low level of butyrate. It should be considered to administer butyrate supplementation to CRC pa-tients especially prior to surgery to support an appropriate preparation to this treatment.

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