Publications Repository - Gdańsk University of Technology

Nitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e,&14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 2.72 mM, 0.23 0.12 mM, and 7.58 1.01 mM, respectively. Further studies demonstrated that these compounds can change cellular and nuclear morphology and inhibit colony formation in the tested cancer cells. They also remarkably block/inhibit the cell cycle progression of cancer cells at various phases. DNA damage analysis and apoptosis studies revealed that these compounds have the potential to induce DNA double-strand breaks and apoptosis. In silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the potent compounds were assessed, revealing that all the compounds exhibited favorable pharmacokinetic and toxicological properties. The potent compounds identified from this study can be considered as a lead for further drug design and development.

Authors

• K. Fabitha,
• Anoop Kallingal link open in new tab ,
• dr inż. Natalia Maciejewska link open in new tab ,
• C. G. Arya,
• Munugala Chandrakanth,
• Neethu Mariam Thomas,
• Yupeng Li,
• Ramesh Gondru,
• Manne Munikumar,
• Janardhan Banothu