Publications Repository - Gdańsk University of Technology

Despite the exceptional self-regeneration properties of bone, severe injuries often require additional surgical intervention such as using artificial bone constructs. These structures need to meet a number of criteria regarding their structure, performance, alongside the rate and the mechanism of erosion and fracture when implanted, for stimulating the regeneration of defected bone and, more critically providing support in the interim. Technological development in the fields of imaging and additive manufacturing enables taking a huge step forward toward preparing personalized implants with characteristics matching the requirements of the specific injury. From biomaterials point of view, greener and more sustainable biomaterials from renewable resources are on demand for bone regeneration; moreover, bone repair necessitates engineering properties and performance, e.g. mechanical properties. Currently, potential processing methods are not merely limited to 3D printing, but also include 4D and 5D printing methods, considering time, dimension, and rotational degrees of freedom. A wide varieties of the aforementioned processes and techniques enable the application of metals, their alloys, ceramics, and polymers, providing an extremely wide spectrum of possibilities for implant design. Herein, the critical aspects of green biomaterials applied in bone tissue engineering, their application in bone repair and regeneration are summarized, and novel directions in bone tissue engineering are proposed for future developments. Eventually, the latest advances in the application of green biomaterials in clinics are outlined.

Authors

• mgr inż. Balbina Makurat-Kasprolewicz link open in new tab ,
• Hossein Ipakchi,
• Pouya Rajaee,
• dr hab. inż. Agnieszka Ossowska link open in new tab ,
• dr inż. Aleksander Hejna,
• Mehdi Farokhi,
• PhD Fatemeh Mottaghitalab,
• Małgorzata Pawlak,
• Navid Rabiee,
• Mariusz Belka,
• Tomasz Baczek,
• dr Mohammad Reza Saeb link open in new tab