Publications Repository - Gdańsk University of Technology

Bisphosphonates (BPs) are an important treatment for osteoporosis and bone metastases due to their low toxicity, high thermostability, and the ability to inhibit bone resorption. Notably, BPs like alendronate, which contain a primary amine group, exhibit potent antiresorptive and antiangiogenic properties. Recent studies have focused on enhancing the BP properties by incorporating bioactive metals to increase their therapeutic potential. Here, we describe the synthesis and physicochemical properties of new silver etidronate and alendronate salts. Our research demonstrates the potential of silver bisphosphonate complexes in promoting osteoblast viability while exhibiting significant antimicrobial activity. Moreover, silver/sodium alendronates turned out to be rare examples of molecular solid solutions that allow the adjustment of the concentration of potentially cytotoxic silver cations within the obtained compounds.

Authors

• Karolina Gutmańska link open in new tab ,
• dr inż. Michał Bartmański link open in new tab ,
• dr hab. n. med. Anna Ronowska,
• dr inż. Marta Prześniak-Welenc link open in new tab ,
• dr hab. inż. Piotr Szweda link open in new tab ,
• dr hab. inż. Sebastian Demkowicz link open in new tab ,
• Mikołaj Walter link open in new tab ,
• prof. dr hab. inż. Tomasz Klimczuk link open in new tab ,
• prof. dr hab. inż. Anna Dołęga link open in new tab