Repozytorium publikacji - Politechnika Gdańska

A general facile method to synthesize the N-gamma-alkyl and N-gamma,N-gamma-dialkyl derivatives of L-glutamine (1a-d) from L-glutamic acid as a starting substrate is presented. The obtained compounds are shown to inhibit three diferent glutamine-utilizing enzymes, namely: glutaminase, gamma-glutamyl transpeptidase, and glucosamine-6-phosphate synthase, with inhibitory constants within the milimolar range.

Autorzy

• Marta Prokop link otwiera się w nowej karcie ,
• Justyna Czarnecka,
• prof. dr hab. inż. Maria Jolanta Milewska link otwiera się w nowej karcie