Repozytorium publikacji - Politechnika Gdańska

Thirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural basis for homoisocitrate dehydrogenase inhibition was revealed by molecular modeling ofthe enzyme-inhibitor complex. On the other hand, the trimethyl ester forms of some of the novel compounds exhibited antifungal effects. The highest antifungal activity was found for trimethyl trans-homoaconitate, which inhibited growth of some human pathogenicyeasts with minimal inhibitory concentration (MIC) values of 16-32 mcg/mL.

Autorzy

• prof. dr hab. inż. Maria Jolanta Milewska link otwiera się w nowej karcie ,
• Marta Prokop link otwiera się w nowej karcie ,
• dr hab. inż. Iwona Gabriel link otwiera się w nowej karcie ,
• dr hab. inż. Marek Wojciechowski link otwiera się w nowej karcie ,
• prof. dr hab. inż. Sławomir Milewski link otwiera się w nowej karcie