Repozytorium publikacji - Politechnika Gdańska

1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives are of interest for pharmaceutical research as a core structure for synthesis of biological active substance - Etodolac (selective Cyclooxygenase-2 inhibitor, which belongs to the Non-steroidal Anti-inflammatory Drug, NSAID, that shows a clin-ically effective analgesic and anti-inflammatory activity). Here the way of synthesis of two 1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives, impurities of Etodolac generated dur-ing drug production process, is presented. The title compounds were prepared in eight steps procedure which differs from previ-ously reported with respect to the way of constructing 1,3,4,9-tetrahydropyranring in molecule. Moreover, reaction conditions have been optimised and more efficient purification methods were introduced.

Autorzy

• dr inż. Andrzej Stanisław Skwarecki link otwiera się w nowej karcie