Repozytorium publikacji - Politechnika Gdańska

The preliminary diagnostic utility of two mixtures of Toxoplasma gondii recombinant antigens (rROP1+rSAG2 and rROP1+rGRA6) in IgG ELISA and IgG avidity test has been evaluated. A total of 173 serum samples from patients with toxoplasmosis and seronegative people were examined. The sensitivity of IgG ELISA for rROP1+rSAG2 and rROP1+rGRA6 was 91.1% and 76.7%, respectively, while the reactivity for sera from patients where acute toxoplasmosis was suspected was higher, at 100% and 95.4%, respectively, than for people with chronic infection, at 88.2% and 70.6%. In this study a different trend in avidity maturation of IgG antibodies for two mixtures of proteins in comparison with native antigen was observed. The results suggest that a new IgG avidity test using the mixtures of recombinant antigens may be useful for the diagnosis of difficult-to-identify phases of toxoplasmosis. For this reason, selected mixtures after the additional tests on groups of sera with well-defined dates of infection could be used as a better alternative to the native antigens of the parasite in the serodiagnosis of human T. gondii infection.

Autorzy

• Dorota Drapała link otwiera się w nowej karcie ,
• dr hab. inż. Lucyna Holec-Gąsior link otwiera się w nowej karcie ,
• prof. dr hab. Józef Kur link otwiera się w nowej karcie ,
• dr inż. Bartłomiej Ferra link otwiera się w nowej karcie ,
• dr Elżbieta Hiszczyńska-Sawicka link otwiera się w nowej karcie ,
• Dariusz Lautenbach