Repozytorium publikacji - Politechnika Gdańska

Objective:The discovery of sequence specific gene silencing which occurs due to the presence of double-stranded RNAs has considerable impact on biology, revealing an unknown level of regulation of gene expression. This process is known as RNA interference (RNAi) or RNA silencing in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecule. Two types of small RNA molecules - small interfering RNA (siRNA) and microRNA (miRNA) are central to RNA interference. Therefore, SiMiSnoRNA database has been developed to focus on the efficient storage of RNA interferences or small RNA sequences and qualitative analysis of its structures across variety of organisms. Method:SiMiSnoRNA database is developed using WAMP server which implements Apache, MySQL, and PHPas principal components. Result and Conclusion:A flexible web-based search engine is developed to obtain fast access to specific small RNA sequence information. BLAST search analysis within SiMiSnoRNA enables users to compare their own query sequence data with SiMiSnoRNA database to retrieve related information. To facilitate data consistency, publicly available information from NCBI has been integratedinto database that can be conveniently used for research on the experimental and molecular biology. Database URL: http://smsrna.chem.pg.gda.pl

Autorzy

• Umesh Kalathiya link otwiera się w nowej karcie ,
• Monikaben Padariya link otwiera się w nowej karcie ,
• prof. dr hab. inż. Maciej Bagiński link otwiera się w nowej karcie ,
• Chintankumar Padariya link otwiera się w nowej karcie