Repozytorium publikacji - Politechnika Gdańska

Drug interactions are often desirable particularly in medicine, when treatment of a patient requires using a mixture of drugs in specific doses to produce the adequate therapeutic effect. Unfortunately, interactions between drugs in the environment are not as desirable, despite the fact that drugs are present in the environment at low concentration levels [1]. Pharmaceuticals are present in the environment in a mixture of compounds, which are not inert towards each other, may contribute to the increase (phenomenon of synergism) or decrease (phenomenon of antagonism) of overall toxicity [2]. Pharmaceuticals namely: diclofenac (sodium salt), oxyteracycline hydrochloride, fluoxetine hydrochloride and chloramphenicol, were mixed with each other at different ratios of EC50 and tested using MICROTOX®. Results obtained show the highest toxicity exhibited by mixtures containing diclofenac.

Autorzy

• dr inż. Monika Wieczerzak link otwiera się w nowej karcie ,
• dr hab. inż. Błażej Kudłak link otwiera się w nowej karcie ,
• prof. dr hab. inż. Jacek Namieśnik link otwiera się w nowej karcie